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Publications from NeuroSearch
2010
Dyhring, T., Nielsen E.Ø., Sonesson, C., Pettersson, F., Karlsson, J., Svensson, P., Christophersen, P. & Waters N. The dopaminergic stabilizers pridopidine (ACR16) and (-)-OSU6162 display dopamine D(2) receptor antagonism and fast receptor dissociation properties. Eur J Pharmacol. (2010) 628: 19-26.
Mikkelsen, J.D., Thomsen, M.S., Hansen, H.H. & Lichota, J. Use of biomarkers in the discovery of novel anti-schizophrenia drugs. Drug Discovery Today (2010) 15(3-4): 137-141.
Thomsen, M.S., Hay-Schmidt, A., Hansen, H.H & Mikkelsen, J.D. Distinct Neural Pathways Mediate a7 Nicotinic Acetylcholine Receptor--Dependent Activation of the Forebrain. Cerebral Cortex (2010)
Thorsen, T.S., Madsen, K.L., Rebola, N., Rathje, M., Anggono, .V, Bach, A., Moreira, I.S., Stuhr-Hansen, N., Dyhring, T., Peters, D., Beuming, T., Huganir, R., Weinstein, H., Mulle, C., Strømgaard, K., Rønn, L.C. & Gether, U. Identification of a small-molecule inhibitor of the PICK1 PDZ domain that inhibits hippocampal LTP and LTD. Proc Natl Acad Sci U S A. (2010) 107(1): 413-418.
2009
Andreasen J.T., Nielsen. E.Ø. & Redrobe, J.P. Chronic oral nicotine increases brain [3H]epibatidine binding and responsiveness to antidepressant drugs, but not nicotine, in the mouse forced swim test. Psychopharmacology (Berl). (2009); 205(3):517-28.
Andreasen, J.T., Olsen, G.M., Wiborg, O. & Redrobe, J.P. Antidepressant-like effects of nicotinic acetylcholine receptor antagonists, but not agonists, in the mouse forced swim and mouse tail suspension tests. J Psychopharmacol. (2009); 23(7):797-804.
Andreasen J.T. & Redrobe, J.P. Antidepressant-like effects of nicotine and mecamylamine in the mouse forced swim and tail suspension tests: role of strain, test and sex. Behav Pharmacol. (2009); 20(3):286-95.
Andreasen J.T. & Redrobe, J.P.Nicotine, but not mecamylamine, enhances antidepressant-like effects of citalopram and reboxetine in the mouse forced swim and tail suspension tests. Behav Brain Res. (2009); 197(1):150-156.
Bentzen, B.H., Osadchii, O., Jespersen, T., Hansen, R.S., Olesen, S.-P. & Grunnet M. Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury. Pflugers Arch. (2009) 457: 979-988.
Briggs, C.A., Grønlien, J.H., Curzon, P., Timmermann, D.B., Ween, H., Thorin-Hagene, K., Kerr, P., Anderson, D.J., Malysz, J., Dyhring, T., Olsen, G.M., Peters, D., Bunnelle, W.H. & Gopalakrishnan, M. Role of channel activation in cognitive enhancement mediated by alpha7 nicotinic acetylcholine receptors. Br. J. Pharmacol. (2009) 158: 1486-1494.
Bunnelle, W.H., Tietje, K.R., Frost, J.M., Peters, D., Ji, J., Li, T., Scanio, M.J., Shi, L., Anderson, D.J., Dyhring, T., Grønlien, J.H., Ween, H., Thorin-Hagene, K. & Meyer MD. Octahydropyrrolo[3,4-c]pyrrole: a diamine scaffold for construction of either alpha4beta2 or alpha7-selective nicotinic acetylcholine receptor (nAChR) ligands. Substitutions that switch subtype selectivity. J. Med. Chem. (2009) 52(14): 4126-4141.
Butini, S., Gemma, S., Campiani, G., Franceschini, S., Trotta, F., Borriello, M., Ceres, N., Ros, S., Coccone, S.S., Bernetti, M., De Angelis, M., Brindisi, M., Nacci, V., Fiorini, I., Novellino, E., Cagnotto, A., Mennini, T., Sandager-Nielsen, K., Andreasen, J.T., Scheel-Kruger, J., Mikkelsen, J.D. & Fattorusso, C. Discovery of a new class of potential multifunctional atypical antipsychotic agents targeting dopamine D3 and serotonin 5-HT1A and 5-HT2A receptors: design, synthesis, and effects on behavior. J Med Chem. (2009) 52(1): 151-169.
Calloe, K., Cordeiro, J.M., Di Diego, J.M., Hansen, R.S., Grunnet, M., Olesen, S.P. & Antzelevitch, C. A transient outward potassium current activator recapitulates the electrocardiographic manifestations of Brugada syndrome. Cardiovasc. Res. (2009) 81(4): 686-694
Deuther-Conrad, W., Fischer, S., Hiller, A., Nielsen, E.Ø., Timmermann, D.B., Steinbach, J., Sabri, O., Peters, D. & Brust, P. Molecular imaging of α7 nicotinic acetylcholine receptors: design and evaluation of the potent radioligand [18F]NS10743.Eur. J. Nucl. Med. Mol. Imaging (2009) 36(5): 791-800.
Diness, J.G., Hansen, R.S., Nissen, J.D., Jespersen, T. & Grunnet, M. Antiarrhythmic effect of IKr activation in a cellular model of LQT3. Heart Rhythm (2009) 6 (1): 100-106.
Fanoe, S., Jensen, G.B., Sjøgren. P., Korsgaard, M.P. & Grunnet M. Oxycodone is associated with dose-dependent QTc prolongation in patients and low-affinity inhibiting of hERG activity in vitro. Br. J. Clin. Pharmacol. (2009) 67(2): 172-179.
Hougaard C, Fraser MO, Chien C, Bookout A, Katofiasc M, Jensen BS, Rode F, Bitsch-Nørhave J, Teuber L, Thor KB, Strøbaek D, Burgard EC, Rønn LC. A positive modulator of K Ca 2 and K Ca 3 channels,4,5-dichloro-1,3-diethyl-1,3-dihydro-benzoimidazol-2-one (NS4591), inhibits bladder afferent firing in vitro and bladder overactivity in vivo. J Pharmacol Exp Ther. 2009; 328(1):28-39.
Hougaard C, Jensen ML, Dale TJ, Miller DD, Davies DJ, Eriksen BL, Strøbaek D, Trezise DJ, Christophersen P. Selective activation of the SK1 subtype of human small-conductance Ca2+-activated K+ channels by 4-(2-methoxyphenylcarbamoyloxymethyl)-piperidine-1-carboxylic acid tert-butyl ester (GW542573X) is dependent on serine 293 in the S5 segment. Mol Pharmacol. (2009); 76(3):569-78.
Jacobsen JP, Redrobe JP, Hansen HH, Petersen S, Bond CT, Adelman JP, Mikkelsen JD, Mirza NR. Selective cognitive deficits and reduced hippocampal brain-derived neurotrophic factor mRNA expression in small-conductance calcium-activated K+ channel deficient mice. Neuroscience. (2009); 163(1):73-81.
Kjaer K, Strøbaek D, Christophersen P, Rønn LC. Chloride channel blockers inhibit iNOS expression and NO production in IFNgamma-stimulated microglial BV2 cells. Brain Res. (2009); 1281:15-24. Erratum in: Brain Res. (2009); 1291:153.
Korsgaard MP, Strøbaek D, Christophersen P. Automated planar electrode electrophysiology in drug discovery: examples of the use of QPatch in basic characterization and high content screening on Na(v), K(Ca)2.3, and K(v)11.1 channels. Comb Chem High Throughput Screen. (2009); 12(1):51-63. Review.
Korsgaard, M.P., Strøbæk, D. & Christophersen, P. Automated Planar Electrode Electrophysiology in Drug Discovery: Examples of the Use of QPatch in Basic Characterization and High Content Screening on Na(v), K(Ca)2.3, and K(v)11.1 Channels. Comb Chem High Throughput Screen. (2009) 12(1): 51-63.
Malysz, J., Grønlien, J.H., Timmermann, D.B., Håkerud, M., Thorin-Hagene, K., Ween, H., Trumbull, J.D., Xiong, Y., Briggs, C.A., Ahring, P.K., Dyhring, T. & Gopalakrishnan, M. Evaluation of alpha7 nicotinic acetylcholine receptor agonists and positive allosteric modulators using the parallel oocyte electrophysiology test station. Assay Drug Dev. Technol. (2009) 7(4): 374-390.
Mikkelsen JD, Bentsen AH, Ansel L, Simonneaux V, Juul A. Comparison of the effects of peripherally administered kisspeptins. Regul Pept. (2009); 152(1-3): 95-100.
Mikkelsen JD, Simonneaux V. The neuroanatomy of the kisspeptin system in the mammalian brain. Peptides. (2009); 30(1): 26-33. Review.
Munro G, Ahring PK, Mirza NR. Developing analgesics by enhancing spinal inhibition after injury: GABAA receptor subtypes as novel targets. Trends Pharmacol Sci. (2009); 30(9):453-9. Review.
Munro G. Comment on Biogenic amine depletion as a putative animal model of fibromyalgia. Pain (2009); 146: 26-33.
Munro G. Pharmacological assessment of the rat formalin test utilizing the clinically used analgesic drugs gabapentin, lamotrigine, morphine, duloxetine, tramadol and ibuprofen: influence of low and high formalin concentrations. Eur J Pharmacol. (2009); 605(1-3): 95-102.
Redrobe J.P. & Nielsen AN. Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. Behav Brain Res. (2009); 198(2):481-5.
Redrobe J.P., Nielsen, E.Ø., Christensen, J.K., Peters, D., Timmermann, D.B. & Olsen, G.M. Alpha7 nicotinic acetylcholine receptor activation ameliorates scopolamine-induced behavioural changes in a modified continuous Y-maze task in mice. Eur J Pharmacol. (2009); 602(1): 58-65.
Revel F.G., Masson-Pévet, M., Pévet, P., Mikkelsen, J.D. & Simonneaux, V. Melatonin controls seasonal breeding by a network of hypothalamic targets. Neuroendocrinology. (2009); 90(1): 1-14. Review.
Simonneaux, V., Ansel, L., Revel, F.G., Klosen, P., Pévet, P. & Mikkelsen, J.D. Kisspeptin and the seasonal control of reproduction in hamsters. Peptides (2009), 30(1): 146-53.
Thomsen MS, Christensen DZ, Hansen HH, Redrobe JP, Mikkelsen JD. alpha(7) Nicotinic acetylcholine receptor activation prevents behavioral and molecular changes induced by repeated phencyclidine treatment. Neuropharmacology. (2009); 56(6-7):1001-9.
Tosco, P., Ahring, P.K., Dyhring, T., Peters, D., Harpsøe, K., Liljefors, T. & Balle T. Complementary three-dimensional quantitative structure-activity relationship modeling of binding affinity and functional potency: a study on alpha4beta2 nicotinic ligands. J. Med. Chem. (2009) 52(8): 2311-2316.
2008
Bundzikova, J., Pirnik, Z., Zelena, D., Mikkelsen, J.D. & Kiss, A. Response of Substances Co-Expressed in Hypothalamic Magnocellular Neurons to Osmotic Challenges in Normal and Brattleboro Rats. Cell Mol Neurobiol. (2008) 28 (8):1033-1047.
Butini, S., Pickering, D.S., Morelli, E., Coccone, S.S., Trotta, F., De Angelis, M., Guarino, E., Fiorini, E., Campiani, G., Novellino, E., Schousboe, A., Christensen, J.K. & Gemma, S.1H-Cyclopentapyrimidine-2,4(1H,3H)-dione-Related Ionotropic Glutamate Receptors Ligands. Structure-Activity Relationships and Identification of Potent and Selective iGluR5 Modulators. J. Med. Chem. (2008) 51: 6614–6618.
Cimarosti, H., Lindberg, C., Bomholt, S.F., Rønn, L.C. & Henley, J.M. Increased protein SUMOylation following focal cerebral ischemia. Neuropharmacology (2008) 54(2):280-9
Diness, T.G., Yeh, Y.-H., Qi, X.Y., Chartier, D., Tsuji, Y., Hansen, R.S., Olesen, S.-P., Grunnet, M. & Nattel, S. Antiarrythmic properties of a rapid delayed-rectifier current activator in rabbit models of acquired long QT syndrome. Cardiovasc Res. (2008) 79(1): 61-69.
Giorgioni, G., Ruggieri, S., Claudi, F., Di Stefano, A., Ljung, E. & Carlsson, T. Synthesis and Pharmacological Evaluation of 4-Phenoxy-1,2,3,4-Tetrahydroisoquinolines and 4,5,6,6a-Tetrahydrochromeno[2,3,4-de]isoquinolines. Med. Chem. (2008) 4(1): 1-10.
Grunnet, M. Fetal arrhythmia caused by dysregulation og HERG channels. Heart Rhythm (2008) 5(5): 562-564.
Hansen, R.H., Olesen, S.-P., Rønn, L.C.B. & Grunnet, M. In vivo effects of the IKr agonist NS3623 on cardiac electrophysiology of the Guinea pig. J Cardiovasc. Pharmacol. (2008) 52 (1): 35-41.
Jørgensen, S., Nielsen, E.Ø., Peters, D. & Dyhring, T. Validation of a flourescence-based high-throughput assay for the measurement of neurotransmitter transporter uptake activity. J. Neurosci. Meth. (2008) 169: 168-176.
Lager, E., Nilsson, J., Nielsen, E.Ø., Nielsen, M., Liljefors, T.& Sterner, O. Affinity of 3-acyl substituted 4-quinolones at the benzodiazepine site of GABAA receptors. Bioorganic & Medicinal Chemistry (2008) 16: 6936–6948.
Larsen, A.P., Olesen, S.-P., Grunnet, M. & Jespersen, T. Characterization of hERG1a and hERG1b potassium channels – a possible role for hERG1b in the IKr current. Pflugers Arch. (2008) 456: 1137-1148.
Lehr, T., Staab, A., Tillmann, C., Nielsen, E.Ø., Trommeshauser, D., Schaefer, H.G. & Kloft, C. Contrib |
